This is a non-surgical, minimally invasive technique for men with Peyronie’s Disease. It involves injecting a medical substance called collagenase directly into the scar tissue which can cause the penile curvature.

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Peyronie’s disease is a common issue that occurs in many men as they get older. This disease causes a condition that men describe as bent penis or curved penis.

Approximately three and a half percent to nine percent of men have Peyronie’s disease, depending on age.

Some men experience pain with erections, which causes problems with having sex and can result in stress and anxiety.

Intralesional injections are generally the most effective and most common treatment for Peyronie’s disease. 


Intralesional injections are performed in an outpatient setting. You will need an initial consultation to assess the degree of curvature and point of maximum curvature. The patient is given an injection to create an erection to enable the consultant to perform the required measurements.

Two further outpatient appointments are made for you within 7 days of each other. You will receive an injection of Collagenase into the scar tissue at each of these appointments. The consultant will need to stretch your penis manually and based on his previous measurements and feeling for the scar, he will inject directly into the scar tissue.


You will experience some discomfort, swelling and bruising for up to a week after each injection. Simple painkillers can be taken once you are home.

The consultant will apply a pressure bandage to your penis which needs to be kept in place for approximately 6 hours post injection. Try to elevate your penis with padding or gauze to help alleviate swelling and bruising.

You should abstain from sexual penetrative intercourse for six weeks. Having erections during this time is advised though. The consultant/nurse will advise you on how to use the vacuum device therapy following your second injection.

You may drive yourself home.

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Use the secure form to send a message regarding any concerns you may have. Should you have any information regarding a referral from a GP please also include this and we will be in touch with next steps.

18 Devonshire Street, London W1G 7AF

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